Which statement best describes the major collagen type in the vitreous?

Which statement best describes the major collagen type in the vitreous?

• A. Predominantly Type 2
• B. Predominantly Type 1
• C. Predominantly Type 3
• D. Predominantly Type 4

Answer: (A)

Type II collagen forms the main structural network of the vitreous, giving it its gel-like, transparent consistency. It creates slender fibrils that are interwoven with proteoglycans such as hyaluronic acid, producing a hydrated, viscoelastic matrix essential for optical clarity and stable retinal support. While other collagens are present in smaller amounts—type IX helps regulate the spacing and stability of the type II fibrils, and types I, III, or IV are more characteristic of other ocular structures or basement membranes—the dominant collagen in the vitreous is type II.

Type II collagen forms the main structural network of the vitreous, giving it its gel-like, transparent consistency. It creates slender fibrils that are interwoven with proteoglycans such as hyaluronic acid, producing a hydrated, viscoelastic matrix essential for optical clarity and stable retinal support. While other collagens are present in smaller amounts—type IX helps regulate the spacing and stability of the type II fibrils, and types I, III, or IV are more characteristic of other ocular structures or basement membranes—the dominant collagen in the vitreous is type II.